This study is being conducted to determine the safety of repeat metered cryospray (MCS) treatment in patients with COPD with chronic bronchitis previously treated with MCS.
Subject has completed a previous MCS study, including both treatments (treatment day 1 and treatment day 2)
Males and females <80 years of age
Subject is able to read, understand, and sign a written informed consent form in order to participate in the study
Subject has a diagnosis of chronic obstructive pulmonary disease (COPD) with chronic bronchitis (CB) for a minimum of two years. (CB is defined clinically as chronic productive cough for 3 months in each of 2 successive years in a patient in whom other causes of productive cough have been excluded)
Subject has had an acute pulmonary infection, exacerbation or pneumonia requiring medical treatment (with antibiotics and/or steroids) within 4 weeks prior of initially planned study bronchoscopy
Subject has other origins of respiratory disease aside from CB and COPD
Subject is using e-cigarettes, vaping or inhaled substances not prescribed by a physician
Subject has untreatable or life-threatening arrhythmias, inability to adequately oxygenate during the bronchoscopy, or has acute respiratory failure