Repeated Bout Effect i Neuromuscular Diseases
ConditionMyopathy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMads Peter Godtfeldt Stemmerik
About this trial
The repeated bout effect (RBE) refers to the adaptation whereby a single bout of eccentric exercise protects against muscle damage from subsequent eccentric bouts. This effect has been shown in many muscle groups using both serum biomarkers, muscle soreness and imaging techniques. Though the effect is well described in healthy, it has never been studied in patients with neuromuscular diseases (NMDs).
In healthy, the RBE is only described using eccentric exercise, but unlike healthy persons, patients with NMDs can experience significant muscle damage with concentric exercise. This raises the question, if patients with NMDs could also show RBE when performing concentric exercise.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age > 18 years
The ability to complete the exercise challenge
No concurrent medical condition that could interfere with interpretation of the results
Molecular diagnosis of the specific condition in specified patient groups or healthy control
Disqualifiers
Cardiac or pulmonary disease contraindicating peak exercise testing or strenuous exercise defined as NYHA-class III-IV
Veins that are too difficult to puncture for blood sampling, evaluated by the investigator
Severe muscle weakness, that prevents the subject completing the exercise test, evaluated by the investigator
Trial design
Design model
Single group
Treatments tested in this trial
Exercise
Other interventionEither concentric or excentric exercise
Treatment groups
50 Participants
are divided into 1 treatment groupGroup A: Exercise challengeOther 1 intervention
Trial outcomes
Primary outcomes
1
Delta CK
Change in peak kreatine kinase following first and second exercise bout.
Time frame
1 monthSponsors and contacts
Click on the lead sponsor to view all of their trials.
Mads Peter Godtfeldt Stemmerik
Lead sponsor
Rigshospitalet, Denmark
Sponsor institution
Source ClinicalTrials.gov