Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age6-20
SponsorCook Children's Health Care System

About this trial

This project examines the use of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach to improve motor function in children with cerebral palsy (CP). By applying 6-Hz primed low and high-frequency rTMS and measuring brain responses through TMS-EEG, the study aims to enhance neural plasticity and motor recovery. The goal is to promote faster rehabilitation and reduce long-term healthcare needs.

Eligibility criteria

Qualifiers

Aged 6 - 20 years,

A confirmed diagnosis of CP by a specialized professional (pediatric neurologist, PM&R physician, neonatal developmental specialist, or neonatologist) is a prerequisite for participation,

Classified as high functioning (Level I, II, or III) according to the Gross Motor Function Classification System (GMFCS),

Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,

Disqualifiers

Syndromic or genetic brain-related associations,

History of major trauma or brain surgery,

Inability to remain still,

History of Epilepsy,

Trial design

Treatments tested in this trial

  • MRI
  • HD-EEG Recording
  • rTMS

Treatment groups

60 Participants
are divided into 4 treatment groups