Endovascular therapy (EVT) added on best medical management is currently recommended in acute large vascular occlusion (LVO) stroke patients with National Institutes of Health Stroke Scale (NIHSS) score \>5. Thus, a sizeable fraction of patients with a minor stroke that do not undergo cerebrovascular screening may experience an early neurological deterioration (END) due to LVO, possibly leading to poor long-term functional outcome. However, whether these patients may still benefit from a rescue EVT is unknown, especially in a late window (\>24 hours). In this study, the investigators assume that best medical management plus EVT might be superior than best medical management alone in a late window for minor stroke patients who have experienced an LVO and END. The primary objective of the study was to establish the safety and efficacy of EVT in a late window for minor stroke patients in the anterior circulation who experienced an LVO and END.
Age ≥ 18 years；
Presenting with symptoms consistent with an AIS and the initial NIHSS score <6 points；
Symptom progression within 7 days of first onset；
Randomization can be finished > 24 hours of stroke onset (stroke onset time is defined as last known well time)；
Pre-stroke mRS score >1;
Imaging confirms the progression of symptoms caused by intracranial hemorrhage, brain edema, or other clear causes;
The target vessel may have factors that may prevent it from completing endovascular treatment, such as a diameter less than 1.5mm, a tortuous vascular pathway, difficulty in reaching the target position with instruments, or difficulty in recovery;
Severe stenosis or occlusion of multiple blood vessels;
First Affiliated Hospital of Wannan Medical College
Lead sponsor
The First Affiliated Hospital of Anhui Medical University
Collaborator
Xiangtan Central Hospital
Collaborator
The First Affiliated Hospital of Hainan Medical University
Collaborator
Huang Shan People's Hospital
Collaborator
Fuyang people's hospital
Collaborator
Linyi People's Hospital
Collaborator
Jiujiang No.1 People's Hospital
Collaborator
Taihe Hospital
Collaborator