BIOCOR is an interventional clinical trial whose main objectives are Objectif are identify molecular biomarker(s) of ocular rosacea and pachychoroid. Endpoints are : Correlation between pachychoroidosis (defined by choroidal phenotype parameters in OCT and autofluorescence) or the stage of ocular rosacea (ROSCO(29) definition) and biological markers selected on the basis of preclinical work (animal model) and by unbiased methods (proteomics, metabolomics, meibum lipidomics). The study of circulating, ocular and functional biomarkers would enable us to confirm our hypothesis and identify patients who could benefit from treatments that regulate the ANS and/or mineralocorticoid pathways.
Male or female > 18 years of age, of European origin, with signed ± genetic consent
Clear ocular media for OCT and autofluorescence imaging
Signed consent form
Be affiliated to a health insurance scheme
High myopia > 6D
Diabetic retinopathy, hereditary retinal dystrophy, untreated retinal detachment, choroidal ocular tumor, choroidal hemangioma
Epithelial or stromal keratopathy other than ocular rosacea
Corneal surgery less than 3 months old, keratoplasty
Clinact
Lead sponsor
Association CRO - Tous unis pour la vision
Collaborator