Respiratory Muscles and Work of Breathing in Children

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age0-17
SponsorAssistance Publique - Hôpitaux de Paris

About this trial

Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology of respiratory impairment and guide therapeutic management. The use of an invasive technique (esogastric probe) makes it possible to specifically explore the diaphragm, the accessory inspiratory muscles and the expiratory muscles in order to detect dysfunction or paralysis of these muscles, and to estimate the work of breathing in order to better guide the respiratory management.

The primary objective of the study is to evaluate the respiratory effort in children with primary or secondary impairment of the respiratory muscles during spontaneous breathing or during mechanical ventilation.

Eligibility criteria

Qualifiers

Patients aged less than 18 years old with primary or secondary impairment of respiratory muscles and followed at Necker Hospital

Patients under spontaneous breathing or noninvasive or invasive mechanical ventilation

Written informed consent

Disqualifiers

No social insurance

Significant psychomotor retardation

Absence of cooperation

Significant agitation

Trial design

Treatments tested in this trial

  • Esogastric pressure measurement

Treatment groups

550 Participants
are divided into 1 treatment group

Sponsors and collaborators

Assistance Publique - Hôpitaux de Paris

Lead sponsor

URC-CIC Paris Descartes Necker Cochin

Collaborator