This study aims to analyze changes in the immune status, metabolic status, and host microbiome community structure in non-valvular atrial fibrillation patients with intracardiac thrombus. Additionally, the study aims to analyze factors that influence the responsiveness and occurrence of adverse events related to anticoagulant therapy.
Age ≥18 years old, age ≤80 years old
Patients with atrial fibrillation detected by routine surface 12-lead electrocardiography or Holter
Transesophageal echocardiography confirmed the presence of cardiac thrombus, and the patient had not received any anticoagulant therapy
Echocardiography confirmed valvular heart disease
Contraindications to anticoagulants
Patients with the previous history of hemorrhagic stroke
Low platelet count or functional platelet defects
First Affiliated Hospital Xi'an Jiaotong University
Lead sponsor
521 Hospital of NORINCO Group
Collaborator
Shaanxi Provincial People's Hospital
Collaborator
Xiangyang Central Hospital
Collaborator
Henan Provincial People's Hospital
Collaborator