About this trial
The aim of this study is to determine whether restricted fluid intake (135 ±5 mL/kg/day) compared to liberal fluid intake (165 ±5 mL/kg/day) from day 8 of life reduces the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks postmenstrual age or prior death in preterm infants born \<30 weeks gestational age.
Eligibility criteria
Qualifiers
Hospitalised preterm infants born before 30 weeks 0 days gestation
Signed informed consent for further research use of health-related data
Disqualifiers
congenital malformations
diseases likely to affect life expectancy, lung function, fluid strategy, or neurodevelopment
renal disease requiring fluid management outside the clinical standard of care
congenital heart disease not including patent ductus arteriosus (PDA)
Trial design
Treatments tested in this trial
- Fluid restriction
- Liberal fluid intake
Treatment groups
Sponsors and collaborators
University Children's Hospital Basel
Lead sponsor
Swiss Neonatal Network
Collaborator
SwissPedNet
Collaborator