Restricted Versus Liberal Fluid Intake for Prevention of Bronchopulmonary Dysplasia

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age8+
SponsorUniversity Children's Hospital Basel

About this trial

The aim of this study is to determine whether restricted fluid intake (135 ±5 mL/kg/day) compared to liberal fluid intake (165 ±5 mL/kg/day) from day 8 of life reduces the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks postmenstrual age or prior death in preterm infants born \<30 weeks gestational age.

Eligibility criteria

Qualifiers

Hospitalised preterm infants born before 30 weeks 0 days gestation

Signed informed consent for further research use of health-related data

Disqualifiers

congenital malformations

diseases likely to affect life expectancy, lung function, fluid strategy, or neurodevelopment

renal disease requiring fluid management outside the clinical standard of care

congenital heart disease not including patent ductus arteriosus (PDA)

Trial design

Treatments tested in this trial

  • Fluid restriction
  • Liberal fluid intake

Treatment groups

750 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University Children's Hospital Basel

Lead sponsor

Swiss Neonatal Network

Collaborator

SwissPedNet

Collaborator