Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure
ConditionAcute Heart Failure (AHF)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorGødstrup Hospital
About this trial
The aim of this clinical trial is to learn whether a thirst-driven, liberal fluid-intake strategy is comparable to a fluid-restriction strategy in patients hospitalized for acute decompensated heart failure (ADHF). The study will also assess the safety of the intervention and its effects on thirst and quality of life.
Patients hospitalized with ADHF will be asked to follow either a thirst-driven fluid-intake strategy or a fluid-restriction strategy during their hospital stay and for one month after discharge.
Eligibility criteria
Qualifiers
Age >18 years
≥1 documented symptom of new or worsening heart failure (dyspnea, fatigue, decreased exercise tolerance, or symptom of end-organ hypoperfusion).
Treatment with ≥40 mg IV furosemide (or equivalent)
Enrolment within 24 hours of admission
Disqualifiers
Requirement at admission for ICU-level care, or IV inotropic/vasopressor therapy for ADHF.
Na+ <125 mmol/L or Na+ >145 mmol/L.
End-stage chronic kidney disease on chronic dialysis or eGFR <15 mL/min/1.73 m2
Any condition which would make participation unsafe or substantially affect protocol adherence, as judged by investigator.
Trial design
Treatments tested in this trial
- Fluid restriction strategy
- Thirst-driven, liberal fluid intake
Treatment groups
420 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov