This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.
Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)
Adults without neurodegenerative disease
Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.
Eyes that have had intraocular surgery, other than cataract surgery.
Duke University
Lead sponsor
University of Edinburgh in Scotland
Collaborator
Tan Tock Seng Hospital in Singapore
Collaborator
Queens University of Belfast United Kingdom
Collaborator