Retinal Vessel Leakage in Cerebral Small Vessel Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Edinburgh
About this trial
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are:
* Does retinal vessel leakage occur in cerebral small vessel disease? * If it does, is the severity of retinal vessel leakage similar to the severity of cerebral small vessel disease generally?
Participants will be tested using fluorescein angiography. This involves an intravenous injection of fluorescent dye, and is a very sensitive way to find leakage from retinal blood vessels.
Participants will have already had brain scans and other examinations and tests to measure the severity of their cerebral small vessel disease. Our new retinal images will complement the information from these previous tests.
Eligibility criteria
Qualifiers
Membership in the Mild Stroke Study 3 cohort
Contrast enhanced MRI within 12 months
Clear optical media in both eyes, as assessed by study investigator
Best corrected visual acuity (near vision) ≥N36
Disqualifiers
Any condition known to cause retinal leakage (i.e., worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, malignant hypertension)
Previous treatment for retinal leakage (retinal laser, intravitreal anti-VEGF)
Recent eye surgery
Shallow anterior chambers as assessed by torch test
Trial design
Treatments tested in this trial
- Fundus fluorescein angiography, with ultrawide field retinal imaging
Treatment groups
No treatment groups listed
Sponsors and collaborators
Source ClinicalTrials.gov