Rhythm Psychophysics With Parkinson's Patients

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-80
SponsorMcMaster University

About this trial

The goal of this interventional study is to understand how the rhythmic abilities of individuals in the early stages of Parkinson's Disease (PD) are impacted by their levels of dopamine. The main questions it aims to answer are:

* Does dopamine shelter the ability to generate and maintain a regular tapping rhythm in the presence of disrupting sensory information? * Does dopamine allow the adaptation of tapping speed in the presence of changing sensory information? * Is the engagement of the motor system useful to improve the detection of changes in the tempo of sensory information?

Participants will be asked to perform a battery of simple rhythmic tasks On and Off medication to evaluate the effect of dopamine on their rhythmic skills.

Eligibility criteria

Qualifiers

Parkinson's Disease diagnostic

Stage 1 or 2 Hoenh-Yahr scale

Taking immediate-release Levodopa

MoCA score of 26 or above

Disqualifiers

Dementia

Other neurodegenerative disease

History of substance abuse

History of hearing disorders

Trial design

Treatments tested in this trial

  • Withholding Levodopa

Treatment groups

34 Participants
are divided into 1 treatment group

Sponsors and collaborators