Risk Assessment and Mechanism Analysis of Intracranial Multiple Aneurysm Instability Based on High-resolution Magnetic Resonance, Imaging Histology and Hemodynamics

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorZhujiang Hospital

About this trial

This project proposes to establish a prospective cohort of MIA based on a preexisting multicenter MIA database and to combine multidimensional methods such as high-resolution magnetic resonance, hemodynamics, ambulatory blood pressure, and imaging histology to study aneurysm instability.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18-80 years old, male or infertile female;

Diagnosed as IA (intracranial aneurysm) through CTA, MRA, or DSA; And it is suitable for endovascular intervention treatment

The patient and/or their legal representative or guardian fully understand the research purpose, voluntarily participate and sign informed consent Books;

Patients willing to cooperate with high-resolution magnetic resonance imaging.

Disqualifiers

AVM (arteriovenous malformation), Moyamoya disease, or DAVF (dural arteriovenous fistula) related aneurysms;

Patients with contraindications for high-resolution magnetic resonance imaging;

Participants in clinical trials of other drugs or medical devices;

Patients with severe underlying diseases and extremely poor clinical conditions who cannot tolerate general anesthesia surgery;

Trial population

Inclusion Criteria: 1\. be older than 18 years of age; 2. complete a high-resolution magnetic resonance exam Exclusion Criteria: 1\. aneurysm combined with other cerebrovascular diseases; 2. substandard image quality

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

High resolution MRI aneurysm features

Enhancement grade was defined as follows: grade 0 for none enhancement, grade 1 for focal enhancement, involved the neck, the intermediate portion, the dome, or a bleb;grade 2 for thin annular enhancement (maximum thickness≤1 mm) , grade 3 for thick annular enhancement(maximum thickness\>1 mm) .

Time frame
1 year

Secondary outcomes

1

postoperative mRS score

MRS score definition: The MRS score, also known as the Modified Rankin Scale, is a scale used to evaluate the neurological recovery status of stroke patients. It is divided into seven levels, Level 0: completely asymptomatic. Level 1: Despite symptoms, without obvious disabilities, able to complete all frequently engaged work and activities. Level 2: Mild disability, unable to complete all work and activities, but able to handle personal affairs without the need for assistance from others. Level 3: Moderate disability, requiring assistance from others to walking without assistance. Level 4: Severe disability, unable to walk without the help of others, unable to take care of one's own needs. Level 5: Severe disability, bedridden, urinary and fecal incontinence, requiring continuous care, and requiring multiple 24-hour care from others. Level 6: Death. The higher the mRS score, the worse the patient's prognosis.

Time frame
1 year
2

postoperative aneurysm occlusion rate

Raymond classification, grade I: complete embolism; Grade II: residual aneurysm neck;

Time frame
1 year

Other outcomes

Sponsors and contacts

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