Risk Assessment Evaluation for Identifying Participants at High Risk for Stomach Cancer

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-80
SponsorCity of Hope Medical Center

About this trial

This clinical trial evaluates the usefulness of various risk assessment tests, including Helicobacter pylori (H. pylori) breath testing, questionnaires, and endoscopies for identifying participants at high risk for stomach cancer. H. pylori is a bacteria that causes stomach inflammation and ulcers in the stomach. People with H. pylori infections may be more likely to develop cancer in the stomach. H. pylori breath testing can help identify the presence of H. pylori infection in a participant and help identify if the participant may be at a higher risk of developing stomach cancer. An endoscopy uses a thin, flexible lighted tube that is inserted inside the esophagus, stomach, and first part of the small intestine. This allows the doctor to see and look for abnormal areas that may need to be biopsied. Risk assessment including H. pylori evaluation, questionnaires, and endoscopies may help identify participants at high risk for stomach cancer and may be a useful screening tool for earlier stomach cancer diagnosis.

Eligibility criteria

Qualifiers

Documented informed consent of the participant and/or legally authorized representative

Assent, when appropriate, will be obtained per institutional guidelines

Age: ≥ 40 years to ≤ 80 years

Identify as a racial minority either Asian, Hispanic, or Black American

Disqualifiers

Identify as Non-Hispanic White

History of gastric cancer

Known premalignant lesions of the stomach

History of upper endoscopy within 2 years

Trial design

Treatments tested in this trial

  • Biopsy
  • Biospecimen Collection
  • Breath Test
  • Esophagogastroduodenoscopy
  • Questionnaire Administration

Treatment groups

240 Participants
are divided into 3 treatment groups

Sponsors and collaborators

City of Hope Medical Center

Lead sponsor

National Cancer Institute (NCI)

Collaborator