Risk-guided Disease Management Plan to Prevent Heart Failure in Patients Treated With Previous Chemotherapy (REDEEM)

ConditionHeart Failure
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-85
SponsorBaker Heart and Diabetes Institute

About this trial

This is a prospective study in which a process of identifying and reducing heart failure (HF) risk will be applied to cancer survivors \>55 years old with chemotherapy \>5 years ago.

The overall goal of this study to identify the feasibility and value of risk-guided cardiac rehabilitation (exercise, risk factor modification, and behavioural support) as a component of survivorship care.

Eligibility criteria

Qualifiers

History of cancer > 10 years ago

Have received potentially toxic chemotherapy Anthracycline (any dose) Trastuzumab (Herceptin) in breast-cancer with the HER2 mutation OR Tyrosine kinase inhibitors (e.g. sunitinib) OR Left chest radiotherapy

Disqualifiers

Ejection fraction at baseline echo <50%

Valvular stenosis or regurgitation of >moderate severity

History of previous heart failure (baseline New York Heart Association (NYHA) classification >2)

Systolic BP <110 mmHg

Trial design

Treatments tested in this trial

  • Heart Failure intervention (Cardio-Oncology Disease Management Plan (CO-DMP)
  • Usual care

Treatment groups

685 Participants
are divided into 2 treatment groups