About this trial
Although the primary knee motion occurs in flexion/extension, the frontal and transverse (off-axis) knee motions are smaller but crucial for maintaining joint stability and normal knee loading. Altered kinematics and neuromuscular control in off-axis knee motions have been reported in patients with knee osteoarthritis (OA), which are associated with excessive knee loading and the progression of knee OA. However, traditional rehabilitative treatments for people with knee OA and existing exercise equipment often focus on sagittal plane movement. Probably due to the technical limitations, there is a lack of convenient and effective equipment/method to train patients with knee OA in off-axis (frontal and transverse) planes.
The purpose of this study is to use a robot-aided elliptical training device to measure knee neuromechanical properties and to improve neuromuscular control in off-axis knee motions, aiming for joint de-loading and pain reduction for individuals with knee OA.
Eligibility criteria
Qualifiers
Age 45 - 85 years.
Meets the ACR classification criteria for knee OA (clinical + radiographic criteria); Kellgren-Lawrence grade I-III.
Persistent knee pain ≥ 3 months.
Able to independently complete elliptical training (6 minutes without interruption).
Disqualifiers
Other inflammatory joint diseases (e.g., rheumatoid arthritis).
Knee trauma, surgery, or intra-articular injections within the past year.
History of knee or hip replacement.
Cardiovascular disease or uncontrolled hypertension contradict to exercises.
Trial design
Treatments tested in this trial
- Robot-Aided Off-Axis Neuromuscular Training
- Traditional elliptical regular stepping