Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorRicardo Mora
About this trial
The purpose of this study is to investigate whether the elevated circulating lactate levels of individuals with metabolic syndrome are responsible for their reduced lipolysis and glucose tolerance. The investigators will conduct an intervention study in which blood lactate levels will be elevated via intravenous infusion of sodium lactate. State of the art metabolic assessment using stable isotopes and indirect calorimetry will be used to study alterations in fat and carbohydrate metabolism.
Eligibility criteria
Qualifiers
Men and women
>18 years of age
Women non-pregnant or taking contraceptive medication
Physically active according to WHO's guidelines
Disqualifiers
Chronic illness that prevents them from exercising
Affected blood samples at screening, as assessed by the PI
Assessed as unsuitable by PI
Trial design
Treatments tested in this trial
- hyperlactacidemia
- Saline (0.9%, sterile, for infusion)
Treatment groups
24 Participants
are divided into 2 treatment groupsSponsors and collaborators
Ricardo Mora
Lead sponsor
University of Castilla-La Mancha
Sponsor institution
University of Castilla-La Mancha
Collaborator
Source ClinicalTrials.gov