The recovery of periapical defects linked to periodontal communication frequently yields less satisfactory results. Numerous studies and case reports have highlighted the notable success achieved through the application of guided tissue regeneration techniques. More recently, autologous platelet concentrate plug \& placental membrane have emerged as a treatment option for addressing such lesions. Nevertheless, there has been no study using PRF-Medium with ACM membrane on the healing of aforesaid lesion \& quality of life assessment.
Patients of age 16yrs and above.
Patients with apico-marginal defects and deep pocket upto apex of tooth.
Failed primary root canal treatment.
Presence of interproximal bone loss.
Presence of vertical root fracture
Presence of root perforations
ASA-3 or ASA-4 according to the classification of the American Society of Anesthesiologists)
Presence of root resorption