Role of Medical Thoracoscopy in Pleural Infection (PROMPT Trial)

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversità Politecnica delle Marche

About this trial

The PROMPT study is testing whether an early keyhole procedure called Medical Thoracoscopy, which lets doctors look inside the chest and remove infected fluid, works better than current standard treatment (medicines to break up thick fluid) for people with pleural infection. About 170 patients in several hospitals will be randomly assigned to one of the two treatments, and researchers will see which approach results in fewer additional procedures-such as another drain or surgery-within 30 days, as well as how quickly people recover and whether they experience any complications. Everyone in the study receives high-quality care, and the results will help doctors better understand which treatment gives patients the best chance of recovering quickly and safely

Eligibility criteria

Qualifiers

Adults ≥ 18 years

Clinical and radiological diagnosis of pleural infection (purulent, culture-positive, or pH < 7.2)

Need of pleural drainage

Able and willing to give informed consent

Disqualifiers

Chest drain in situ >24h before randomisation

Post-traumatic pleural effusion

Known allergy to fibrinolytic agents or contraindication to thoracoscopy

Pregnancy or breastfeeding

Trial design

Treatments tested in this trial

  • medical thoracoscopy
  • Standard of Care

Treatment groups

170 Participants
are divided into 2 treatment groups

Locations

This trial has no locations