Role of Transposable Elements in Septic Immune Aging

ConditionsSepsis Sepsis and Septic Shock Sepsis With Multiple Organ Dysfunction (MOD)Sepsis With Acute Organ Dysfunction Sepsis, Severe Sepsis at Intensive Care Unit Sepsis, Severe Sepsis and Septic Shock Sepsis, Septic Shock

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorUniversity of California, San Francisco

About this trial

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is:

1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU?

Participants will have blood drawn from them but will not be subjected to additional interventions.

Eligibility criteria

Qualifiers

Age 18 or older

Admitted to ICU with sepsis (Sepsis 3 Criteria)

SOFA score of at least 2 at time of enrollment

Disqualifiers

Patients on organ transplantation immunosuppression

Patients with preexisting leukopenia

Cancer patients receiving CAR-T therapy

Patients who are under 18 years of age or otherwise deemed pediatric

Trial design

Treatments tested in this trial

RNA and DNA Sequencing

Treatment groups

116 Participants

are divided into 2 treatment groups

Sponsors and collaborators

University of California, San Francisco

Lead sponsor

National Cancer Institute (NCI)

Collaborator

Source ClinicalTrials.gov