rTMS for Tobacco Use in Veterans
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorVA Office of Research and Development
About this trial
Cigarette smoking is a significant public health concern for Veterans. Encouraging smoking cessation continues to be a top priority for the Veterans' Administration as Veterans who use tobacco experience negative health effects, including cancer, heart disease, and mental disorders. Despite the efficacy of current evidence-based pharmacotherapies and psychotherapies for smoking cessation, alternative treatments are critically needed. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of brain stimulation, US FDA-approved for smoking cessation. In this protocol, the investigators propose comparing the two rTMS protocols (standard TMS vs. precision TMS) to find a better treatment parameter for smoking cessation in Veterans. Identifying an efficacious rTMS protocol would benefit Veterans who want to quit smoking.
Eligibility criteria
Qualifiers
Veteran
Males and females between the ages of 18 and 70
Individuals who smoke 10 or more cigarettes per day and have a CO level > 10 ppm indicative of recent smoking
Those who have not received substance abuse treatment within the previous 30 days
Disqualifiers
Current moderate to severe substance use of any psychoactive substances other than nicotine or caffeine, as defined by DSM-V criteria
Contraindications to MRI (e.g., metal in the skull, orbital or intracranial cavity, or claustrophobia)
Contraindications to rTMS (history of a seizure or epilepsy)
A history of autoimmune, endocrine, viral, or vascular disorders affecting the brain
Trial design
Treatments tested in this trial
- Transcranial Magnetic Stimulation
- personalized-image-guided and E-field-modeling dose rTMS (precision TMS)
Treatment groups
56 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov