rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorWest Virginia University

About this trial

This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors linked to ICDs: reinforcement learning and delay-discounting. This is a randomized sham-controlled cross-over trial. All patients will undergo a session of active rTMS and a session of sham rTMS, with the order of sessions randomized across participants. Following recruitment and eligibility screening, the eligible participants will undergo two sessions of rTMS (active and sham), immediately followed by neurocognitive tasks and questionnaires, no more than 1-2 weeks apart. Each session will have a duration of approximately 1-1.5 hours.

Eligibility criteria

Qualifiers

Clinician-confirmed diagnosis of PD

Ability to provide informed consent, written and verbal

Clinician-diagnosed impulse control disorder or impulse control behaviors including punding/hobbyism and dopamine dysregulation syndrome

A Beck Depression Inventory (BDI) (Beck et al., 1961) score of 14 or lower

Disqualifiers

History of seizures or epilepsy

History of brain lesions (such as multiple sclerosis, tumor) reported

History of vascular issues in the brain, such as stroke

History of a moderate to severe traumatic brain injury

Trial design

Treatments tested in this trial

  • rTMS Active
  • rTMS Sham

Treatment groups

20 Participants
are divided into 2 treatment groups

Sponsors and collaborators