About this trial
This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors linked to ICDs: reinforcement learning and delay-discounting. This is a randomized sham-controlled cross-over trial. All patients will undergo a session of active rTMS and a session of sham rTMS, with the order of sessions randomized across participants. Following recruitment and eligibility screening, the eligible participants will undergo two sessions of rTMS (active and sham), immediately followed by neurocognitive tasks and questionnaires, no more than 1-2 weeks apart. Each session will have a duration of approximately 1-1.5 hours.
Eligibility criteria
Qualifiers
Clinician-confirmed diagnosis of PD
Ability to provide informed consent, written and verbal
Clinician-diagnosed impulse control disorder or impulse control behaviors including punding/hobbyism and dopamine dysregulation syndrome
A Beck Depression Inventory (BDI) (Beck et al., 1961) score of 14 or lower
Disqualifiers
History of seizures or epilepsy
History of brain lesions (such as multiple sclerosis, tumor) reported
History of vascular issues in the brain, such as stroke
History of a moderate to severe traumatic brain injury
Trial design
Treatments tested in this trial
- rTMS Active
- rTMS Sham