RTMS Targets Neural Circuits for Smoking Cessation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age22-70
SponsorMedical University of South Carolina
About this trial
Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel, non-pharmacological interventions for depression and cigarette smokers. In this study, investigators will use brain MRI to guide TMS therapy for smoking cessation.
Eligibility criteria
Qualifiers
Be between the ages of 22 and 70 years old.
Smoke 10 or more cigarettes per day and have a carbon monoxide (CO) level > 10 ppm indicative of recent smoking.
Have not received substance abuse treatment within the previous 30 days.
Meet the criteria for tobacco use disorder as determined by DSM-5.
Disqualifiers
Current moderate to severe substance use of any psychoactive substances other than nicotine or caffeine, as defined by DSM-V criteria.
Contraindications to MRI (e.g., presence of metal in the skull, orbital or intracranial cavity, or having claustrophobia).
Contraindication to rTMS.
History of autoimmune, endocrine, viral, or vascular disorders affecting the brain.
Trial design
Treatments tested in this trial
- Sham rTMS
- Active rTMS 10 Hz DLPFC
Treatment groups
64 Participants
are divided into 2 treatment groupsSponsors and collaborators
Medical University of South Carolina
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov