The study will include all patients over 18 years of age who underwent endovascular closure of patent foramen ovale in medical centers in the Russian Federation, who gave written informed consent to the closure and provided personal data as part of inpatient medical care. The project participants will be 29 medical centers in the Russian Federation, where endovascular closure of patent foramen ovale is performed.
Patients with an ischemic event (cryptogenic ischemic stroke, transient ischemic attack, embolism of other organs and systems) associated with a PFO;
Presence of an open oval confirmed by ultrasound diagnostic methods;
Age of patients from 18 years;
Life expectancy of at least 1 year;
Inability to receive antiplatelet therapy;
Presence of acute inflammatory diseases;
Acute stage of cerebral circulatory failure (30 days);
Myocardial infarction or aortocoronary bypass surgery within the previous 30 days;