This is a multicenter, observational real world clinical trial with prospective follow up that will evaluate the treatment outcome of adolescent and young patients with ph-negative acute lymphoblastic leukemia with first-line pediatric-like protocol in Argentina.
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Ph-negative ALL diagnosis without previous treatment.
ALL with mature B phenotype (sIg +) or with the cytogenetic alterations characteristic of ALL mature B (t (8,14), t (2, 8), t (8, 22)).
Ph-positive ALL
Acute leukemias of ambiguous lineage (undifferentiated or mixed phenotype).
Patients with a history of coronary, valvular or hypertensive heart disease, that contraindicate the use of anthracyclines.