Safety and Efficacy of Edoxaban and Rivaroxaban to Cerebral Venous Thrombosis in Chinese Patients

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorXuanwu Hospital, Beijing

About this trial

The goal of this observational study is to learn the safety and efficacy of edoxaban and rivaroxaban in Chinese population with the age range from 18 to 80 years who take edoxaban or rivaroxaban to treat their cerebral venous thrombosis (CVT). The main question it aims to answer are:

* Do cerebral veins or venous sinuses recanalize during the treatment period of edoxaban and rivaroxaban? * Do the bleeding events occur during the treatment period of edoxaban and rivaroxaban?

The main tasks participants will be asked to do:

* Participants will comply fully with the prescribed regimen and take the edoxaban or rivaroxaban as directed at the specified dosage. * Participants will return to hospital for scheduled follow-up assessments at months 3, 6, 9, and 12 post-enrollment to undergo face-to-face visits with investigators.

Eligibility criteria

Qualifiers

Patient aged from 18 to 80 years and no gender preference;

Diagnosis of CVT as confirmed on MRBTI/MRV or CT/CTV or DSA;

Acute or subacute CVT from onset to door within 4 weeks;

The treating clinician irrelevant to the study is of the opinion that the patient is appropriate for edoxaban or rivaroxaban;

Disqualifiers

Patient refuse to take edoxaban or rivaroxaban to treat CVT;

Pregnancy or breastfeeding women at the time of enrollment, or women who plan to get pregnant during study;

Patient is anticipated to require invasive procedure (e.g. thrombectomy, hemicraniectomy) prior to initiation of oral anticoagulation;

CVT secondary to central nervous system infection or severe head trauma;

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

1,486 Participants
are grouped into 2 trial groups

Sponsors and collaborators