Remote ischemic conditioning (RIC) is the process of repeated ischemia and reperfusion in the peripheral vessels, which is proved in reducing IRI in vital organs. This IMPROVE trial plans to enroll 648 patients who are diagnosed with coronary artery disease and are going to take off-pump CABG in five centers in China, to access whether RIC can and improve short-term prognosis.
Diagnosed with coronary artery disease and require off-pump CABG surgery.
Between 18 and 75 years old;
Normal left ventricular systolic function (ejection fraction >40%) and left ventricular end-diastolic internal diameter (<60 mm) in the cardiac ultrasound tests;
No or mild heart valve and great vessel abnormalities which do not require surgical intervention;
Severe tissue injuries.
Myalgia, fractures and other peripheral vascular lesions.
Bypass graft being the radial artery.
Stenosis or severe malformations of the subclavian, jugular and femoral arteries and veins.
First Affiliated Hospital Xi'an Jiaotong University
Lead sponsor
Beijing Anzhen Hospital
Collaborator
People's Hospital of Qinghai Province
Collaborator
The Second Hospital of Yulin City
Collaborator
Baoji Central Hospital
Collaborator