Safety and Feasibility of a Multidisciplinary Programme of Integrated Hospital-home Management With Early Discharge of Patients With Haematological Malignancies Undergoing High-dose Chemotherapy in Hospital

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna

About this trial

Patients undergoing particular intensive and (sub)myeloablative chemotherapy regimens with subsequent autologous stem cell transplant currently have a relatively low rate of therapy-related complications, both infectious and non-infectious (organ damage), and can therefore benefit from a specific multidisciplinary care programme at home. In this clinical context, early discharge and domicile of the patient after therapy provided in a hospital setting may represent a procedure designed to better intercept the patient's personal needs. In addition, it may make it possible to increase the limited availability of beds in the face of the progressive increase in demand, allowing the provision of hospital therapies to a higher number of patients with a consequent reduction in pre-hospital waiting times.

Eligibility criteria

Qualifiers

Diagnosis of haematological malignancy undergoing high-dose chemotherapy (sub- or myeloablative)

Age between 18-75 years

WHO Performance Status < 2 or Karnofsky ≥ 60%

FE≥ 50% and absence of significant electrocardiographic changes

Disqualifiers

Diagnosis of haematological malignancy at onset or in progression

Significant cardiovascular disease: heart failure NYHA class 3 or 4, uncontrolled angina, history of myocardial infarction, unstable angina or stroke in the previous 6 months, uncontrolled hypertension, significant arrhythmias not controlled by medication

Trial design

Treatments tested in this trial

  • Home patient management
  • Hospital patient management

Treatment groups

100 Participants
are divided into 2 treatment groups