This is a prospective observational patient registry study designed to evaluate the safety and quality of life associated with three treatment strategies for patients diagnosed with low-risk papillary thyroid microcarcinoma (PTMC): surgical resection, thermal ablation, and active surveillance.
The study aims to collect standardized, real-world clinical data from participating centers. Patients will receive one of the three treatment strategies according to clinical judgment and personal preference. The study team will prospectively follow participants to record safety events, disease progression, and patient-reported quality of life outcomes.
By comparing the outcomes among the three treatment groups, this registry seeks to provide evidence to support personalized and evidence-based decision-making for the management of low-risk PTMC.
A single papillary thyroid carcinoma (PTC) lesion with a maximum diameter ≤ 1 cm confirmed by imaging.
No evidence of extrathyroidal extension on imaging studies.
No clinical or radiologic evidence of cervical lymph node metastasis.
No evidence of distant metastasis.
Ultrasound-confirmed tumor with a maximum diameter > 1 cm.
Imaging findings (ultrasound/CT/MRI) suggestive of extrathyroidal extension.
Tumor located adjacent to critical structures (e.g., trachea, esophagus, or recurrent laryngeal nerve) with possible invasion risk.
History of thyroidectomy, radiofrequency/microwave/laser ablation, or radioactive iodine therapy.