Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age2-5
SponsorNatural Resources Institute Finland
About this trial
The prevalence of atopic dermatitis has increased along with urbanization and biodiversity loss. According to biodiversity hypothesis, the main reason is urban lifestyle and reduced contact to microbial diversity. Previous studies indicate association between atopic dermatitis and exposure to natural microbes in childhood.
Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis, alters commensal microbiota and modifies immune regulation in children.
Eligibility criteria
Qualifiers
Eczema Area and Severity Index ≥ 2
Disqualifiers
Eczema Area and Severity Index < 2
Immune deficiencies, i.e., antibody deficiency
Immunosuppressive systematic medications
A disease affecting immune response (e.g., colitis ulcerosa, rheumatoid arthritis, Crohn's disease, diabetes)
Trial design
Treatments tested in this trial
- Microbial intervention
- Placebo
Treatment groups
80 Participants
are divided into 2 treatment groupsSponsors and collaborators
Natural Resources Institute Finland
Lead sponsor
Tampere University
Collaborator
Source ClinicalTrials.gov