The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD.
We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia.
The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.
None
Children / primary caregivers not providing informed consent to participate
Children not attending one of the selected schools
Thomas Pilgrim
Lead sponsor
Insel Gruppe AG, University Hospital Bern
Sponsor institution
Centre for Infectious Disease Research in Zambia (CIDRZ)
Collaborator
National Academy of Medical Sciences, Nepal
Collaborator
University of Oxford
Collaborator