Screening for Lung Cancer in Subjects With Family History of Lung Cancer
ConditionLung Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50-75
SponsorThe University of Hong Kong
About this trial
Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 50-75, men or women, smokers or non-smokers
Being first degree relatives (Siblings, children, and parents) of lung cancer subjects
Having no known lung cancer before
Disqualifiers
Non-Chinese
Mentally incompetent to give informed consent
Trial population
Subjects with lung cancer and to invite them to participate by (i) naming their first degree relatives to be further invited for the following study procedures, and (ii) provide a blood and urine sample as detailed below for archival and future analysis of relevant biomarkers. The patients' first degree relatives will be contacted by PA's research team and invited for study participation with the following study procedures.
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Low dose CT thorax
Diagnostic testA multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.
Low dose CT thorax
Diagnostic testControl subjects will also proceed to CT thorax, and outcome measures be compared to subjects
Treatment groups
1,520 Participants
are divided into 2 treatment groupsGroup A: First degree relatives of lung cancer patients1 intervention
Group B: Control group1 intervention
Trial outcomes
Primary outcomes
1
The rate of lung cancer detection in subjects with family history of lung cancer
The number of screening-detected lung cancer among first degree relatives of lung cancer patients.
Time frame
An average of 2.5 yearsSecondary outcomes
1
The characteristics of screening detected lung cancer
Stage distribution of lung cancer detected.
Time frame
An average of 2.5 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
The University of Hong Kong
Lead sponsor
The Queen Elizabeth Hospital
Collaborator
Kwong Wah Hospital
Collaborator
Hong Kong Sanatorium & Hospital
Collaborator
Source ClinicalTrials.gov