Observational, feasibility study investigating biological aspects in patients with liver metastasis from colorectal cancer undergoing treatment with SIRT, by translational analysis of biological samples.
Diagnosis of metastatic colorectal adenocarcinoma with liver dominant disease
Diagnosis of liver metastasis may be made by histo- or cyto-pathology, or by clinical and imaging criteria.
The Liver metastasis are not eligible for resection, RFA or SBRT
All patients must be off all chemotherapeutic regimens for 14 days prior to SIRT treatment
Pretherapeutic work-up procedure with Tc-99m macroaggregated albumin (MAA) scintigraphy showing extrahepatic foci in GI-tract
Evidence of any detectable Tc-99m macroaggregated albumin deposition in the stomach or duodenum, after application of established angiographic techniques to stop such deposition
Previous radiation therapy to the lungs and/or to the upper abdomen overlapping with dose to the liver at interventionist´s decision
Lung shunt greater than 20% or > 30 Gray radiation absorbed dose to the lungs, at estimated by Tc-99m-MAA