Cisplatin-combination chemotherapy causes inevitably DNA damage by platinum-DNA adduct formation of both tumor cells but also healthy cells. It therefore stands to reason that testicular cancer treatment causes an increased burden of senescent cells, which causes upregulation of the SASP resulting in a pro-inflammatory phenotype. The investigators hypothesize that this may be an important mechanism behind development of late effects and an early ageing phenotype after treatment for testicular cancer.
Diagnosed with metastatic testicular cancer in 1999-2012 (stage II or higher)
Received first-line cisplatin-based chemotherapy
Was younger than 50 years of age at start of chemotherapy
Diagnosis of metastatic testicular cancer (stage II or higher)
None
University Medical Center Groningen
Lead sponsor
Dutch Cancer Society
Collaborator