Senescent Endometrial Cells in Patients with Thin Endometrial Lining
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-39
SponsorTrio Fertility
About this trial
The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is:
Are there any senescent cells present in thin endometrial lining?
During the luteal phase of the cycle, participants will will undergo:
* Gynecologic US to measure the endometrial lining thickness and pattern. * Endometrial biopsy with Pipelle catheter
Eligibility criteria
Qualifiers
Age 18-39
BMI - up to 35
Thin endometrium after OCP use
Asherman's syndrome
Disqualifiers
Women with systemic disease (Rheumatic disease, DM)
Women with coagulopathies
Women with active pelvic inflammatory process
Uterine anomalies
Trial design
Treatments tested in this trial
- Endometrial Biopsy
Treatment groups
100 Participants
are divided into 3 treatment groupsSponsors and collaborators
Trio Fertility
Lead sponsor
University of Toronto
Sponsor institution
Source ClinicalTrials.gov