About this trial
This study is a multicentre, randomized, double-blind, controlled trial that aims to investigate the efficacy of multi-domain life-style intervention including low inflammatory-index diet, exercise, and cognitive training in patients with mild cognitive impairment and mild Alzheimer's disease.
Eligibility criteria
Qualifiers
Aged 60-90 years
In accordance with the diagnostic criteria for "mild cognitive impairment due to Alzheimer's disease" or "mild Alzheimer's disease" from the National Institutes of Health National Institute on Aging-Alzheimer's Association (NIA-AA) (2011)
The Hamilton depression rating scale/17 edition (HAMD) total score≤10
Neurological examination: no obvious signs
Disqualifiers
Other causes of cognitive decline: cerebrovascular disease, central nervous system infection, Creutzfeldt-Jakob disease, Huntington's and Parkinson's disease, Creutzfeldt-Jakob disease, traumatic brain dementia, other physical and chemical factors (such as drugs, alcohol, CO), systemic disease (hepatic encephalopathy, pulmonary encephalopathy, etc.), intracranial occupation (a subdural hematoma, brain tumor), the endocrine system disease (thyroid disease, parathyroid disease), and vitamins deficiency or any other causes of dementia
The history of nervous system diseases, including stroke, optic myelitis, Parkinson's disease, epilepsy, etc
Psychiatric patients, including schizophrenia or other mental illnesses, bipolar disorder, major depression, or delirium
There are unstable or serious heart, lung, liver, kidney, endocrine, and hematopoietic system diseases, or Poor prognosis because of malignant diseases such as tumors.
Trial design
Treatments tested in this trial
- Diet intervention
- Exercise
- Cognitive training
Treatment groups
Sponsors and collaborators
Ruijin Hospital
Lead sponsor
Shanghai Sinopharm Nursing Care Center
Collaborator