Short Course Radiotherapy
ConditionCentral Nervous System Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeUp to 21
SponsorAbramson Cancer Center at Penn Medicine
About this trial
This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous system malignancies.
Eligibility criteria
Qualifiers
Male or female, aged 21 years or below
Lansky performance status >= 40
Originates outside the brain but is metastatic to 1 or more sites within the brain, or originates and recurs within the brain. For this diagnosis to be confirmed, there must be multidisciplinary review of up to date imaging at a pediatric tumor board with unanimous consensus of intracranial relapse or metastasis. If the consensus is not unanimous, short-interval repeat imaging with subsequent unanimous consensus would be required in order for this eligibility criteria to be met
Has at least 1 targetable intracranial lesion as seen on imaging
Disqualifiers
Radiotherapy for curative intent
Serious uncontrolled systemic or psychiatric disorders that would interfere with participation in the protocol
Being planned for proton radiation
Trial design
Treatments tested in this trial
- Short Course Radiotherapy
Treatment groups
15 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov