About this trial
The goal of this clinical trial is to compare the short-term effects of three commonly prescribed antihypertensive drug classes (beta-blockers, ACE inhibitors, and calcium channel blockers) on postural balance and fall risk in adults with newly diagnosed primary hypertension. The main questions it aims to answer are:
* Do different antihypertensive drugs affect objective balance performance and fall risk? * What are the effects of these medications on dizziness and fear of falling?
Researchers will use a balance analysis system (Biodex Balance System) and self-reported scales (Dizziness Handicap Inventory and Falls Efficacy Scale) to assess outcomes. Participants will:
* Be randomly assigned to one of three drug groups (metoprolol, ramipril, or amlodipine) * Be evaluated at baseline (prior to treatment), at 2 weeks, and at 4 weeks after starting treatment * Complete balance tests and questionnaires at each time point
This study aims to provide clinical insight into how commonly used blood pressure medications may impact balance and fall risk in real-world settings.
Eligibility criteria
Qualifiers
Aged between 18 and 75 years
Newly diagnosed with primary hypertension
No prior use of antihypertensive medication
No history of neurological, vestibular, orthopedic, or psychiatric conditions affecting balance
Disqualifiers
Secondary hypertension
Known diagnosis of vestibular disorders (e.g., BPPV, Ménière's disease)
Use of medications that may affect balance (e.g., sedatives, psychotropic drugs)
History of falls due to trauma unrelated to balance
Trial design
Treatments tested in this trial
- Beta Blocker
- ACE inhibitor
- Calcium channel blocker