Single Step Protocol and Multi-step Warming Protocol for Blastocyst FET
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18+
SponsorMỹ Đức Hospital
About this trial
The multi-step thawing protocol with a reduction of non-permeable cryoprotectant concentrations to reduce osmotic shock caused by the rapid influx of water. Recent studies have shown that a simplified warming protocol by only a thawing solution gave a comparable survival rate but increased pregnancy rate, reduced patients' waiting time, and decreased the workload of embryologists.
Eligibility criteria
Qualifiers
Women aged from 18
Undergoing no more than 3 previous IVF/ICSI cycles
Had at least a single good-quality blastocyst frozen.
Endometrium preparation using artificial cycle
Disqualifiers
Embryos from cycles after in-vitro maturation, pre-implantation genetic testing (PGT)
Having contraindications for exogenous hormone administration (e.g., breast cancer, thromboembolic disease)
Having uterine abnormalities (e.g., adenomyosis, intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx or endometrial polyp)
Trial design
Treatments tested in this trial
- Single-step warming protocol by thawing solution only
- Standard warming protocol
Treatment groups
816 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov