Single vs Hypofractionated Irradiation For Timely Access to Partial Breast Radiotherapy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age40+
SponsorBritish Columbia Cancer Agency
About this trial
Partial Breast Irradiation (PBI) is a targeted radiation approach commonly administered post-lumpectomy, specifically targeting the tumour bed. This targeted therapy reduces the exposure to other nearby tissues such as lungs, heart, and chest wall. However, traditional PBI treatment involves lengthy multiple fraction courses which presents a burden to patients from rural and remote communities, who must travel long distances to receive high quality cancer care. The purpose of this study is to compare single fraction (SF) PBI vs. multiple fraction (MF) PBI.
Eligibility criteria
Qualifiers
Female participants age 40 or older
Able to provide informed consent
pTis-2 pN0 cM0 breast cancer, with tumor size <3 cm as per provincial guidelines
Able to complete electronic or paper entry of participant reported outcomes independently or with assistance from caregiver/family/friend/research staff
Disqualifiers
History of non-breast malignancies except adequately treated non-melanoma skin cancers, in situ cancers treated by local excision or other cancers curatively treated with no evidence of disease for ≥ 5 years.
Uncontrolled concurrent malignant cancer
Seroma not visible
Ipsilateral implanted cardiac device
Trial design
Treatments tested in this trial
- Multiple Fraction PBI
- Single Fraction PBI
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov