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Skeletal Muscle Energetics and Fatiguability in Older Individuals

ConditionsHIVHIV Infections
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age60-90
SponsorJohns Hopkins University

About this trial

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Participants who are >= 60 years of age

HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (<100 copies).

HIV serostatus negative participants

Disqualifiers

Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent

Contraindications to MRI

Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity

Significant lower extremity peripheral vascular disease.

Trial population

People with and without HIV, ages 60 and above will be enrolled

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

200 Participants
are grouped into 2 trial groups
Group A: HIV
Group B: Control

Trial outcomes

Primary outcomes

1

Maximal mitochondrial oxidative capacity (VmaxPCr)

Maximal oxidative capacity of leg muscle measured by 31P Magnetic Resonance Spectroscopy (MRS)

Time frame
Baseline
2

Rate of PCr decline during plantar flexion exercise

Time frame
Baseline
3

Six minute walk distance

Time frame
Baseline

Secondary outcomes

1

Skeletal muscle fat content

Time frame
Baseline
2

Gait speed

Time frame
Baseline
3

Frailty status (as measured by the Fried Frailty Index)

Fried frailty index described in J Gerontol A bill Sci-Fi Med Sci-Fi 2001;56:M146-56

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Johns Hopkins University

Lead sponsor

National Institute on Aging (NIA)

Collaborator

Source ClinicalTrials.gov
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