This study aims to examine whether multi-night closed-loop auditory stimulation (CLAS) during sleep can enhance waste clearance and memory consolidation in healthy adults and older adults with subjective cognitive decline or mild cognitive impairment who exhibit elevated brain amyloid levels identified through prior clinical screening. Specifically, the study investigates whether sleep stimulation increases the clearance of plasma biomarkers related to neurodegeneration, improves the brain's waste clearance system, and supports memory consolidation. Participants will undergo five nights each of CLAS and sham (no stimulation) interventions, with a washout period in between. They will also complete clinical assessments, including MRI scans, blood sample collection, and cognitive testing, and will keep track of subjective sleep quality, sleepiness, mood, and fatigue throughout the interventions.
Proficiency in the French language (close to native level) to complete the neuropsychological evaluation and cognitive tests.
MRI compatibility: absence of metallic materials in the body (implants, vascular clips, certain types of orthopedic material, etc.), a pacemaker or other types of stimulators, cochlear implants, or any other electronic devices.
Current or past psychiatric or neurological conditions (except for those directly associated with the patient group).
The presence of severe untreated sleep disorders.
The presence of irregular sleep-wake cycles (due to shiftwork or extreme chronotype).
The presence of moderate depression or high levels of anxiety.
6
Treatment groupsSee each treatment group below.
Erasme University Hospital
Lead sponsor
University of Amsterdam
Collaborator