The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension. Findings from this study will fill the knowledge gap on the underlying mechanisms of dietary sodium intake on cardiovascular disease risk in addition to blood pressure and could provide further evidence on sodium reduction for the prevention of cardiovascular disease.
Men or women aged ≥40 years. Individuals <40 years are at a low risk for clinical and subclinical CVD
Elevated BP or hypertension (systolic BP ≥120 mmHg and diastolic BP ≥80 mmHg with or without use of antihypertensive medications)
Glomerular filtration rate (eGFR) <30 or end-stage renal disease (kidney transplant or chronic dialysis)
History of cardiovascular disease
Shift worker or regularly work at night
Cancer requiring chemotherapy or radiation treatment in the previous two years
Tulane University
Lead sponsor
Johns Hopkins University
Collaborator