About this trial
With this study, the investigators want to investigate whether computerized speech analysis can be used to reliably and objectively detect motor, emotional, and cognitive fluctuations in Parkinson's disease patients.
Eligibility criteria
Qualifiers
Written informed consent
Idiopathic PD according to the Movement Disorders Society Criteria;
Age of participants > 30 and ≤ 75 years;
Treatment with or without bilateral deep brain stimulation in the subthalamic nucleus;
Disqualifiers
Dysarthria caused in addition by a condition other than PD (e.g. stroke, myasthenia);
Clinical diagnosis of aphasia;
Brain disease other than Parkinson's disease (e.g. atypical Parkinsonism, Alzheimer's disease, vascular dementia, multiple sclerosis, stroke, traumatic brain injury, epilepsy, etc.).
Cognitive impairment (Montreal Cognitive Assessment (MoCa) < 24/30 points);
Trial design
Treatments tested in this trial
- Dopaminergic OFF drug state
- DBS OFF state
- Dopaminergic ON drug state
- DBS ON state
Treatment groups
Sponsors and collaborators
Insel Gruppe AG, University Hospital Bern
Lead sponsor
Czech Technical University in Prague
Collaborator