Speech-in-noise Perception in Autism and Fragile X

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age15-35
SponsorChildren's Hospital Medical Center, Cincinnati

About this trial

The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise?

Participants will complete the following:

* hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.

Eligibility criteria

Qualifiers

normal audiograms (PTA ≤ 20 dB HL)

corrected 20/20 vision (Snellen chart)

no history of premature birth (prior to 36 weeks gestation)

no medications known to affect EEG signal

Disqualifiers

Hearing loss or uncorrected vision loss

history of premature birth (prior to 36 weeks gestation)

Trial design

Treatments tested in this trial

  • Mismatch negativity

Treatment groups

60 Participants
are divided into 1 treatment group