sperDNA Fragmentation a a Predictor for Outcome After Varicocelectomy,m
ConditionDNA Damage
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
Age20-45
SponsorAssiut University
About this trial
Varicocele is often associated with infertility and reduction in sperm quality, and it is one of the most common causes of reversible male infertility.
The exact mechanism of infertility caused due to varicocele formation remains unclear. One of the suggested theories is related to increased oxidative stress that causes sperm DNA damage, including DNA fragmentation, and is correlated with the decreased capacity of spermatozoa to fertilize oocytes during normal fertilization and assisted reproduction techniques. This is supported by the evidence that there is a higher prevalence of DNA fragmentation in varicocele patients and a correlation between the presence of varicocele and impaired sperm DNA integrity.
Several tests have been developed to better assess the fertility potential of sperm, including those designed to measure sperm deoxyribonucleic acid (DNA) fragmentation (SDF). The sperm DNA fragmentation index (DFI) is a potential parameter for fertility investigation, reflecting sperm DNA integrity and damage.
Eligibility criteria
Qualifiers
Patients have been diagnosed with VC (GII and GIII) by physical examination and scrotal color Doppler ultrasonography.
Patients with stable relationships.
In the control group, those with high SDF.
Patients with documented infertility.
Disqualifiers
Patients with systemic or endocrine disease, cryptorchidism, hypogonadism, genital infection, hormonal treatment and azoospermic patients.
Recurrent varicocele.
Patients with any other disease that may cause VC (such as external kidney tumor, hydronephrosis, etc.)
Smoker patients and others risk factors (x ray, nuclear) workers
Trial design
Treatments tested in this trial
- Sperm DNA fragmentation
Treatment groups
1 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Source ClinicalTrials.gov