Spinal Anesthesia For Enhanced Recovery After Liver Surgery
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Manitoba
About this trial
This project proposes to compare epidural versus spinal anesthesia in patients having liver resection surgery. The investigators hypothesize that spinal anesthesia will result in improved blood pressure control postoperatively and reduce the amount of intravenous fluids required after surgery. Spinal anesthesia is expected to provide the same pain control benefits as epidurals, with faster recovery of function. Spinal anesthesia may be a simple and effective way to improve and enhance the recovery in the increasing number of patients requiring liver resection.
Eligibility criteria
Qualifiers
Male or female, Adults aged ≥ 18 years (there will be no upper age restriction);
American Society of Anesthesiologists Physical Status classification (ASA-PS) of I to III;
Undergoing subcostal or midline laparotomy for elective liver resection surgery under general anesthesia; if the planned procedure is a combined operation (i.e., concomitant extrahepatic surgery) , the associated procedure should not add more than one hour to the surgical time of the primary hepatic resection procedure alone;
Stated willingness to comply with all study procedures and availability for the duration of the study
Disqualifiers
Emergency surgery;
Age < 18 years;
Planned laparoscopic hepatic resection;
Planned laparotomy incision other than (right) subcostal, midline, or extended midline;
Trial design
Treatments tested in this trial
- Continuous thoracic epidural analgesia
- Spinal anesthesia with intrathecal morphine
- Bupivacaine 0.75% in Dextrose Inj 8.25%
- Morphine
- Bupivacaine 0.25% Preservative-Free Injectable Solution
- Bupicavaine 0.125% epidural solution
- Hydromorphone 10 mcg/mL epidural solution
Treatment groups
128 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov