The investigators will examine the effects of dynamic light therapy on circadian rhythms in delirious intensive care unit (ICU) patients. In a randomized controlled trial (RCT), they will investigate the effects of a specific light algorithm on rhythms of serum melatonin, clock gene expression, the proteome, and metabolome, compared to standard hospital lighting, supported by the data science algorithms to improve vital-based algorithms with light interventions.
Patient capable of giving consent or additionally existing legal caregiver or authorized/spouse representative in case of non-consenting patients in the intensive care unit
Male and female patients with age ≥ 18 years
Expected intensive care unit stay ≥ 2 days
Positive delirium during and up to a maximum of 30 days after study inclusion (determined by CAM-ICU, at least once per shift)
Participation in other clinical studies during the study period and ten days before
Previous ICU treatment during the current hospital stay
Patients with psychiatric diseases
Patients with a history of stroke and known severe residual cognitive deficits