Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversität Münster
About this trial
Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).
In current therapeutic regimes, CRRT is used to strictly prevent azotaemia. Thus recent clinical observations, as well as data from animal testing suggest a link between controlled azotaemia and faster renal recovery in AKI patients.
The aim of the study is to improve renal recovery.
Eligibility criteria
Qualifiers
Adult patients (age ≥18 years)
Critically ill patients with AKI + in need of CRRT
Written informed consent
Disqualifiers
Chronic dialysis dependency
Chronic kidney disease with estimated glomerular filtration rate (eGFR) <30 ml/min/1.73m²
severe liver cirrhosis (Child-pugh C)
severe acidosis (pH < 7,20 at study enrolment)
Trial design
Treatments tested in this trial
- Effluent dose of CRRT
Treatment groups
165 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov