Stereotactic Body Radiotherapy Boost Versus Simultaneous Integrated Boost to Pelvic Nodes Among Patients Receiving Radical Chemoradiation in Carcinoma Cervix

ConditionStage IIIC
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-65
SponsorAll India Institute of Medical Sciences

About this trial

Cervical cancer is a significant cause of morbidity and mortality among women worldwide. Radiotherapy, in combination with chemotherapy or as a standalone treatment, is an effective treatment option for cervical cancer. However, traditional radiotherapy has its limitations, such as the potential for damage to surrounding healthy tissues. Stereotactic Body RadioTherapy (SBRT) is a newer radiotherapy technique that delivers high doses of radiation to the tumor with minimal damage to the surrounding tissues. This study aims to evaluate the safety of Stereotactic Body RadioTherapy to involved node in cervical cancer.

Eligibility criteria

Qualifiers

Patients with stage IIIC cervical cancer

No previous pelvic radiation therapy or surgery

Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

Disqualifiers

Patients with stage I or stage II or stage IV disease.

Patients with prior malignancies or active autoimmune diseases

Uncontrolled medical comorbidity

Trial design

Treatments tested in this trial

  • Stereotactic Body Radiotherapy Boost to Involved Pelvic Lymph Nodes
  • Standard Arm: Simultaneous Integrated Boost to involved pelvic node

Treatment groups

150 Participants
are divided into 2 treatment groups